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KMID : 0363220080460101402
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Korean Journal of Dermatology
2008 Volume.46 No. 10 p.1402 ~ p.1406
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A Case of Early Stage Mycosis Fungoides that was Successfully Treated with a Combination Therapy of PUVA and Interfernon-γ
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Yoo Kwang-Ho
Kim Ji-Young
Kim Yeon-Jin
Seo Seong-Jun
Hong Chang-Kwun
Rho Yong-Kwan
Park Ju-Hee
Li Kap-Sok
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Abstract
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Early stage mycosis fungoides (MF) is known to be responsive to various topical and systemic therapies such as
corticosteroids and ultraviolet light radiation, photochemotherapy with psoralens and whole-body electron beam
irradiation. However, these treatments have all revealed a high relapse rate. Thus, we suggest that more invasive
therapy, including PUVA combined with interferon-γ, is one of the possible treatments for early MF because this
treatment displays a reduced relapse rate. We report here on a case of early stage MF (Stage Ib) that was
successfully treated with PUVA (total dose: 105.7 J/cm2) and intravenous administration of recombinant human
interferon-γ (total 5.4×106 IU), and the patient has been without relapse 1 year after treatment.
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KEYWORD
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Early stage mycosis fungoides, Interfernon-γ, PUVA
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